The Comstock Brothel was located in San Francisco, in the red-light district of Barbary Coast. In 1905, it was ran by Madam Pamela Swynford De Beaufort (while she was still human). It is where Pam first meets Eric and has him turn her into a vampire. It is also the site where Eric is first introduced to Bill (who, at the time, was a naive teenaged vampire and still under the supervision of his maker, Lorena).
- Pam - Madam
- Washcloth Helen - a prostitute working for Madam Pam
- Rubber Ruby (aka "The Chink") - a flexible Asian prostitute appealing to "more exotic fancies"