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The pharmacy is located on the outskirts of Bon Temps, Louisiana.
Tara Thornton arrived to buy her mother some Pepto-Bismol after she ate too much craw-fish; or "Mud-Bugs", as she called them. As Tara walked inside, she soon realized the clerk was none other than Miss Jeanette.
Angered, she stormed out of the store; yet doesn't tell her mother what transpired. ("I Don't Wanna Know")
Scenes at the De Soto Pharmacy were filmed in L.A.'s San Fernando Valley, at a place called De Soto Pharmacy. The real life pharmacy of the same name is located at 20914 Roscoe Blvd, in Canoga Park, California. About 15 miles northwest of Universal Studios Hollywood, the pharmacy stands at the southwest corner of Roscoe Blvd & DeSoto Ave.