Deborah Ann Woll, who is of Irish and German descent, grew up in New York City and went to high school at the Packer Collegiate Institute in Brooklyn. She matriculated at the University of Southern California and has since moved to Los Angeles
She has made guest appearances on several television programs including Life, Aces 'n Eights, ER, CSI: Crime Scene Investigation (17th episode of 8th season, For Gedda), My Name Is Earl, The Mentalist and Law and Order SVU. Woll plays Bill Compton's vampire offspring Jessica on the HBO television series True Blood. Her upcoming roles include Mother's Day, which will be directed by Darren Lynn Bousman, and Little Murder, which co-stars Josh Lucas. In 2011, Deborah is acting with fellow True Blood star Michelle Forbes, in Highland Park.
Deborah's boyfriend, Edward "E.J." Scott, and his family are afflicted with choroideremia, which is a condition that slowly blinds its victim. She uses her celebrity status to help advocate for them and others with the disease. She has been quoted as saying that her boyfriend's bravery in fighting his disability has inspired her own battle with celiac disease, which makes her body intolerant to foods containing gluten.