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On their first meeting, Jesús seems to take an immediate interest in Lafayette, followed by a personal visit to Merlotte's to spend time with Lafayette while he is at work. Jesús and Lafayette take V, which causes them to hallucinate. At one point they see Jesus' ancestor Great Aunt Cecilia.
Later, Lafayette calls Jesus to come to his work, because he was still hallucinating. After Lafayette asks him whats happening, Jesús tells him that he's much more sensitive and open to things after taking V. Jesús explained to Lafayette that when his uncle started teaching him magic he saw things too, things that people wanted to hide.
But it eventually wore off, and after he questions him on what he is, Jesús says that he's a Brujo (witch). Lafayette reacts by saying that he lucked out because he's with a witch who's a nurse that's a dude. ("Evil is Going On")