Lorena had the common powers of a vampire: superhuman strength, speed, and healing. Because of her age, she was stronger and faster than younger vampires such as Bill and Jessica though she weaker than older vampires such as Godric and Eric. Her weaknesses included a stake to the heart, silver, and fire. Sunlight would slowly kill a vampire of her age. She was 249 years old at the time of her death.
"I wish I had known you before you were made. Before you turned hard. I would like to have seen you smile with light in your eyes instead of darkness. That, would have been something" Bill to Lorena
Lorena and Bill had a complicated relationship, as Lorena appeared to truly love Bill, despite her fondness for destruction and death. Bill on the other hand seemed to despise Lorena for making him a vampire and costing him his family.