The Yakuza was a powerful and dangerous Japanese criminal organization found on the HBO original series True Blood. One of the main antagonists in the series' seventh, and final, season, and working for the Yakonomo Corporation, the Yakuza's main objective was to capture ex-televangelist Sarah Newlin in order to use the antidote contained within her blood to synthesize a temporary cure for Hepatitis V, a disease fatal to vampires. The Yakuza members in the series are portrayed to be as ruthless and brutal as the organization in the real world.
They first appear in a flashback where they confront Eric Northman in France and force him to choose between killing his human lover, Sylvie, or Pamela Swynford de Beaufort. After they reject his offer to sacrifice himself, he reluctantly chooses his to save his progeny, sacrificing Sylvie. The Yakuza then fatally stab Sylvie and leave a heartbroken Eric to mourn his dead lover. At a republican party rally, the Yakuza arrive to kill Sarah but instead are drawn into battle with Pam and Eric, who have come for the same reason. Eric manages to exact vengeance on Hiroki, the leader responsible of Sylvie's death, but he is forced to submit when Pam is captured and held hostage. They are then taken to Yakonomo Corp. in silver chains and introduced to the gang's employer, Mr. Gus. Rather than kill them, Gus enlists them to help find Sarah and synthesize a cure for Hep V. After finding her, they return to Fangtasia, where the Yakuza continue to serve as Mr. Gus's enforcers and essentially hold Eric and Pam prisoner, until the two vampires manage to gain the upper hand and kill their captors.